Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

doi:10.1016/j.clnu.2017.03.015

. 2018 Jun;37(3):906-913.

doi: 10.1016/j.clnu.2017.03.015. Epub 2017 Mar 24.

Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

Nerea Becerra-Tomás¹, Andrés Díaz-López¹, Núria Rosique-Esteban², Emilio Ros³, Pilar Buil-Cosiales⁴, Dolores Corella⁵, Ramon Estruch⁶, Montserrat Fitó⁷, Lluís Serra-Majem⁸, Fernando Arós⁹, Rosa Maria Lamuela-Raventós¹⁰, Miquel Fiol¹¹, José Manuel Santos-Lozano¹², Javier Díez-Espino⁴, Olga Portoles⁵, Jordi Salas-Salvadó¹³, PREDIMED Study Investigators

Collaborators, Affiliations

Collaborators

PREDIMED Study Investigators:
M Serra-Mir¹⁴, A Pérez-Heras¹⁴, C Viñas¹⁴, R Casas¹⁴, A Medina-Renom¹⁴, J M Baena¹⁴, M García¹⁴, M Oller¹⁴, J Amat¹⁴, I Duaso¹⁴, Y García¹⁴, C Iglesias¹⁴, C Simón¹⁴, L Quinzavos¹⁴, L Parra¹⁴, M Liroz¹⁴, J Benavent¹⁴, J Clos¹⁴, I Pla¹⁴, M Amorós¹⁴, M T Bonet¹⁴, M T Martín¹⁴, M S Sánchez¹⁴, J Altirriba¹⁴, E Manzano¹⁴, A Altés¹⁴, M Cofán¹⁴, C Valls-Pedret¹⁴, A Sala-Vila¹⁴, M Doménech¹⁴, M Bulló¹⁵, N Babio¹⁵, J Basora¹⁵, R González¹⁵, C Molina¹⁵, F Márquez¹⁵, P Martínez¹⁵, N Ibarrola¹⁵, M Sorlí¹⁵, J García Roselló¹⁵, A Castro¹⁵, F Martin¹⁵, N Tort¹⁵, A Isach¹⁵, M Guasch-Ferre¹⁵, J J Cabré¹⁵, G Mestres¹⁵, F Paris¹⁵, M Llauradó¹⁵, R Pedret¹⁵, J Basells¹⁵, J Vizcaino¹⁵, R Segarra¹⁵, J Frigola¹⁵, J Costa-Vizcaino¹⁵, A Salas-Huetos¹⁵, J Boj¹⁵, D Montañes¹⁵, Christopher Papandreou¹⁵, J Fernández-Ballart¹⁵, P Carrasco¹⁶, C Ortega-Azorín¹⁶, E M Asensio¹⁶, R Osma¹⁶, R Barragán¹⁶, F Francés¹⁶, M Guillén¹⁶, J I González¹⁶, C Sáiz¹⁶, O Portolés¹⁶, F J Giménez¹⁶, O Coltell¹⁶, R Fernández-Carrión¹⁶, P Guillem-Sáiz¹⁶, I González-Monje¹⁶, L Quiles¹⁶, V Pascual¹⁶, C Riera¹⁶, M A Pages¹⁶, D Godoy¹⁶, A Carratalá-Calvo¹⁶, S Sánchez-Navarro¹⁶, C Valero-Barceló¹⁶, S Tello¹⁷, J Vila¹⁷, R de la Torre¹⁷, D Muñoz-Aguayo¹⁷, R Elosua¹⁷, J Marrugat¹⁷, H Schröder¹⁷, N Molina¹⁷, E Maestre¹⁷, A Rovira¹⁸, O Castañer¹⁷, M Farré¹⁷, E Toledo¹⁹, M Ruiz-Canela¹⁹, B Sanjulián¹⁹, A Sánchez-Tainta¹⁹, S Eguaras¹⁹, A Martí¹⁹, P Buil-Cosiales¹⁹, M SerranoMartínez¹⁹, J Diez-Espino¹⁹, A García-Arellano¹⁹, E H Martínez-Lapiscina¹⁹, E Goñi¹⁹, Z Vázquez¹⁹, N Berrade¹⁹, V Extremera-Urabayen¹⁹, C Arroyo-Azpa¹⁹, L García-Pérez¹⁹, J Villanueva-Telleria¹⁹, F Cortés-Ugalde¹⁹, T Sagredo-Arce¹⁹, M D Vigata-López¹⁹, M T Arceiz Campo¹⁹, A Urtasun-Samper¹⁹, M V Gueto Rubio¹⁹, B Churio-Beraza¹⁹, F Arós²⁰, I Salaverria²⁰, T Del Hierro²⁰, J Algorta²⁰, S Francisco²⁰, A Alonso-Gómez²⁰, E Sanz²⁰, J Rekondo²⁰, M C Belló²⁰, A Loma-Osorio²⁰, E Gómez-Gracia²¹, J Wärnberg²¹, R Benítez Pont²¹, M Bianchi Alba²¹, R Gómez-Huelgas²¹, J Martínez-González²¹, V Velasco García²¹, J de Diego Salas²¹, A Baca Osorio²¹, J Gil Zarzosa²¹, J J Sánchez Luque²¹, E Vargas López²¹, V Ruiz-Gutiérrez²², J Sánchez Perona²², E Montero Romero²², M García-García²², E Jurado-Ruiz²², M Fiol²³, D Romaguera²³, M García-Valdueza²³, M Moñino²³, S Munuera²³, M Vivó²³, F Bestard²³, J A Munar²³, L Coll²³, A Proenza²³, R Prieto²³, G Frontera²³, F Fiol²³, M Ginard²³, A Jover²³, J García²³, J M Santos-Lozano²⁴, M Ortega-Calvo²⁴, L Mellado²⁴, F J García-Corte²⁴, P Román²⁴, P Iglesias²⁴, Y Corchado²⁴, L Miró-Moriano²⁴, C Domínguez-Espinaco²⁴, J M Lozano-Rodriguez²⁴, S Vaquero-Diaz²⁴, M C López-Sabater²⁵, A I Castellote-Bargalló²⁵, P Quifer-Rada²⁵, A Tresserra-Rimbau²⁵, J Álvarez-Pérez²⁶, E M Díaz-Benítez²⁶, A Sánchez-Villegas²⁶, L T Casañas-Quintana²⁶, J Pérez-Cabrera²⁶, C Ruano-Rodríguez²⁶, I Bautista-Castaño²⁶, F Sarmiento de la Fe²⁶, J A García Pastor²⁶, B V Díaz-González²⁶, J M Castillo Anzalas²⁶, R E Sosa-Also²⁶, J Medina-Ponce²⁶, E de la Cruz²⁷, M Fanlo-Maresma²⁷, A Galera²⁷, F Trias²⁷, I Sarasa²⁷, E Corbella²⁷, X Corbella²⁷, C Cabezas²⁸, E Vinyoles²⁸, M A Rovira²⁸, L García²⁸, G Flores²⁸, J M Verdú²⁸, P Baby²⁸, A Ramos²⁸, L Mengual²⁸, P Roura²⁸, M C Yuste²⁸, A Guarner²⁸, M I Santamaría²⁸, M Mata²⁸, C de Juan²⁸, A Brau²⁸, J A Tur²⁹, M P Portillo³⁰, G Sáez³¹, F Arós³², M Aldamiz-Echevarría³², A M Alonso-Gómez³², J Berjón³², L Forga³², J Gállego³², A García-Layana³², A Larrauri³², J Portu-Zapirain³², J Timiraus-Fernández³²

Affiliations

¹ Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Institut d'Investigació Sanitària Pere Virgili (IISPV), Rovira i Virgili University, Reus, Spain; Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain.
² Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Institut d'Investigació Sanitària Pere Virgili (IISPV), Rovira i Virgili University, Reus, Spain.
³ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Lipid Clinic, Endocrinology and Nutrition Service, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
⁴ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Atención Primaria, Servicio Navarro de Salud-Osasunbidea, 31010 Navarra, Spain; IdiSNA, Navarra Institute for Health Research, Spain.
⁵ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Preventive Medicine, University of Valencia, Valencia, Spain.
⁶ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Internal Medicine, August Pi i Sunyer Institute of Biomedical Research (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain.
⁷ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Cardiovascular Risk and Nutrition Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona Biomedical Research Park, Barcelona, Spain.
⁸ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
⁹ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Cardiology, University Hospital Araba, Vitoria, Spain.
¹⁰ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Science, INSA-University of Barcelona, Barcelona, Spain.
¹¹ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Institute of Health Sciences, University of Balearic Islands and Son Espases Hospital, Palma de Mallorca, Spain.
¹² Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Family Medicine, Distrito Sanitario Atención Primaria Sevilla, Centro de Salud San Pablo, Sevilla, Spain.
¹³ Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Institut d'Investigació Sanitària Pere Virgili (IISPV), Rovira i Virgili University, Reus, Spain; Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain. Electronic address: jordi.salas@urv.cat.
¹⁴ Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
¹⁵ Rovira i Virgili University, Reus, Spain.
¹⁶ University of Valencia, Valencia, Spain.
¹⁷ Hospital del Mar Research Institute, Barcelona, Spain.
¹⁸ Hospital del Mar Research Institute, Barcelona, Spain; Primary Care Division, Catalan Institute of Health, Barcelona, Spain.
¹⁹ University of Navarra and Osasunbidea (Servicio Navarro de Salud), Primary Care Centres, Pamplona, Spain.
²⁰ University Hospital of Álava, Vitoria, Spain.
²¹ University of Málaga, Málaga, Spain.
²² Instituto de la Grasa, Consejo Superior de Investigaciones Científicas, Sevilla, Spain.
²³ Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain.
²⁴ Department of Family Medicine, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain.
²⁵ School of Pharmacy, University of Barcelona, Barcelona, Spain.
²⁶ Instituto Universitario de Investigaciones Biomédicas y Sanitarias (I.U.I.B.S.) de la Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain.
²⁷ Hospital Universitari de Bellvitge-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
²⁸ Primary Care Division, Catalan Institute of Health, Barcelona, Spain.
²⁹ University of Balearic Islands, Spain.
³⁰ University of Basque Country, Spain.
³¹ University of Valencia, Spain.
³² University Hospital Araba, Spain.

PMID: 28392166
DOI: 10.1016/j.clnu.2017.03.015

Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

Nerea Becerra-Tomás et al. Clin Nutr. 2018 Jun.

. 2018 Jun;37(3):906-913.

doi: 10.1016/j.clnu.2017.03.015. Epub 2017 Mar 24.

Authors

Collaborators

PREDIMED Study Investigators:
M Serra-Mir¹⁴, A Pérez-Heras¹⁴, C Viñas¹⁴, R Casas¹⁴, A Medina-Renom¹⁴, J M Baena¹⁴, M García¹⁴, M Oller¹⁴, J Amat¹⁴, I Duaso¹⁴, Y García¹⁴, C Iglesias¹⁴, C Simón¹⁴, L Quinzavos¹⁴, L Parra¹⁴, M Liroz¹⁴, J Benavent¹⁴, J Clos¹⁴, I Pla¹⁴, M Amorós¹⁴, M T Bonet¹⁴, M T Martín¹⁴, M S Sánchez¹⁴, J Altirriba¹⁴, E Manzano¹⁴, A Altés¹⁴, M Cofán¹⁴, C Valls-Pedret¹⁴, A Sala-Vila¹⁴, M Doménech¹⁴, M Bulló¹⁵, N Babio¹⁵, J Basora¹⁵, R González¹⁵, C Molina¹⁵, F Márquez¹⁵, P Martínez¹⁵, N Ibarrola¹⁵, M Sorlí¹⁵, J García Roselló¹⁵, A Castro¹⁵, F Martin¹⁵, N Tort¹⁵, A Isach¹⁵, M Guasch-Ferre¹⁵, J J Cabré¹⁵, G Mestres¹⁵, F Paris¹⁵, M Llauradó¹⁵, R Pedret¹⁵, J Basells¹⁵, J Vizcaino¹⁵, R Segarra¹⁵, J Frigola¹⁵, J Costa-Vizcaino¹⁵, A Salas-Huetos¹⁵, J Boj¹⁵, D Montañes¹⁵, Christopher Papandreou¹⁵, J Fernández-Ballart¹⁵, P Carrasco¹⁶, C Ortega-Azorín¹⁶, E M Asensio¹⁶, R Osma¹⁶, R Barragán¹⁶, F Francés¹⁶, M Guillén¹⁶, J I González¹⁶, C Sáiz¹⁶, O Portolés¹⁶, F J Giménez¹⁶, O Coltell¹⁶, R Fernández-Carrión¹⁶, P Guillem-Sáiz¹⁶, I González-Monje¹⁶, L Quiles¹⁶, V Pascual¹⁶, C Riera¹⁶, M A Pages¹⁶, D Godoy¹⁶, A Carratalá-Calvo¹⁶, S Sánchez-Navarro¹⁶, C Valero-Barceló¹⁶, S Tello¹⁷, J Vila¹⁷, R de la Torre¹⁷, D Muñoz-Aguayo¹⁷, R Elosua¹⁷, J Marrugat¹⁷, H Schröder¹⁷, N Molina¹⁷, E Maestre¹⁷, A Rovira¹⁸, O Castañer¹⁷, M Farré¹⁷, E Toledo¹⁹, M Ruiz-Canela¹⁹, B Sanjulián¹⁹, A Sánchez-Tainta¹⁹, S Eguaras¹⁹, A Martí¹⁹, P Buil-Cosiales¹⁹, M SerranoMartínez¹⁹, J Diez-Espino¹⁹, A García-Arellano¹⁹, E H Martínez-Lapiscina¹⁹, E Goñi¹⁹, Z Vázquez¹⁹, N Berrade¹⁹, V Extremera-Urabayen¹⁹, C Arroyo-Azpa¹⁹, L García-Pérez¹⁹, J Villanueva-Telleria¹⁹, F Cortés-Ugalde¹⁹, T Sagredo-Arce¹⁹, M D Vigata-López¹⁹, M T Arceiz Campo¹⁹, A Urtasun-Samper¹⁹, M V Gueto Rubio¹⁹, B Churio-Beraza¹⁹, F Arós²⁰, I Salaverria²⁰, T Del Hierro²⁰, J Algorta²⁰, S Francisco²⁰, A Alonso-Gómez²⁰, E Sanz²⁰, J Rekondo²⁰, M C Belló²⁰, A Loma-Osorio²⁰, E Gómez-Gracia²¹, J Wärnberg²¹, R Benítez Pont²¹, M Bianchi Alba²¹, R Gómez-Huelgas²¹, J Martínez-González²¹, V Velasco García²¹, J de Diego Salas²¹, A Baca Osorio²¹, J Gil Zarzosa²¹, J J Sánchez Luque²¹, E Vargas López²¹, V Ruiz-Gutiérrez²², J Sánchez Perona²², E Montero Romero²², M García-García²², E Jurado-Ruiz²², M Fiol²³, D Romaguera²³, M García-Valdueza²³, M Moñino²³, S Munuera²³, M Vivó²³, F Bestard²³, J A Munar²³, L Coll²³, A Proenza²³, R Prieto²³, G Frontera²³, F Fiol²³, M Ginard²³, A Jover²³, J García²³, J M Santos-Lozano²⁴, M Ortega-Calvo²⁴, L Mellado²⁴, F J García-Corte²⁴, P Román²⁴, P Iglesias²⁴, Y Corchado²⁴, L Miró-Moriano²⁴, C Domínguez-Espinaco²⁴, J M Lozano-Rodriguez²⁴, S Vaquero-Diaz²⁴, M C López-Sabater²⁵, A I Castellote-Bargalló²⁵, P Quifer-Rada²⁵, A Tresserra-Rimbau²⁵, J Álvarez-Pérez²⁶, E M Díaz-Benítez²⁶, A Sánchez-Villegas²⁶, L T Casañas-Quintana²⁶, J Pérez-Cabrera²⁶, C Ruano-Rodríguez²⁶, I Bautista-Castaño²⁶, F Sarmiento de la Fe²⁶, J A García Pastor²⁶, B V Díaz-González²⁶, J M Castillo Anzalas²⁶, R E Sosa-Also²⁶, J Medina-Ponce²⁶, E de la Cruz²⁷, M Fanlo-Maresma²⁷, A Galera²⁷, F Trias²⁷, I Sarasa²⁷, E Corbella²⁷, X Corbella²⁷, C Cabezas²⁸, E Vinyoles²⁸, M A Rovira²⁸, L García²⁸, G Flores²⁸, J M Verdú²⁸, P Baby²⁸, A Ramos²⁸, L Mengual²⁸, P Roura²⁸, M C Yuste²⁸, A Guarner²⁸, M I Santamaría²⁸, M Mata²⁸, C de Juan²⁸, A Brau²⁸, J A Tur²⁹, M P Portillo³⁰, G Sáez³¹, F Arós³², M Aldamiz-Echevarría³², A M Alonso-Gómez³², J Berjón³², L Forga³², J Gállego³², A García-Layana³², A Larrauri³², J Portu-Zapirain³², J Timiraus-Fernández³²

Affiliations

¹ Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Institut d'Investigació Sanitària Pere Virgili (IISPV), Rovira i Virgili University, Reus, Spain; Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain.
² Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Institut d'Investigació Sanitària Pere Virgili (IISPV), Rovira i Virgili University, Reus, Spain.
³ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Lipid Clinic, Endocrinology and Nutrition Service, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
⁴ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Atención Primaria, Servicio Navarro de Salud-Osasunbidea, 31010 Navarra, Spain; IdiSNA, Navarra Institute for Health Research, Spain.
⁵ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Preventive Medicine, University of Valencia, Valencia, Spain.
⁶ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Internal Medicine, August Pi i Sunyer Institute of Biomedical Research (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain.
⁷ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Cardiovascular Risk and Nutrition Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona Biomedical Research Park, Barcelona, Spain.
⁸ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
⁹ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Cardiology, University Hospital Araba, Vitoria, Spain.
¹⁰ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Science, INSA-University of Barcelona, Barcelona, Spain.
¹¹ Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Institute of Health Sciences, University of Balearic Islands and Son Espases Hospital, Palma de Mallorca, Spain.
¹² Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Department of Family Medicine, Distrito Sanitario Atención Primaria Sevilla, Centro de Salud San Pablo, Sevilla, Spain.
¹³ Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Institut d'Investigació Sanitària Pere Virgili (IISPV), Rovira i Virgili University, Reus, Spain; Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain. Electronic address: jordi.salas@urv.cat.
¹⁴ Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
¹⁵ Rovira i Virgili University, Reus, Spain.
¹⁶ University of Valencia, Valencia, Spain.
¹⁷ Hospital del Mar Research Institute, Barcelona, Spain.
¹⁸ Hospital del Mar Research Institute, Barcelona, Spain; Primary Care Division, Catalan Institute of Health, Barcelona, Spain.
¹⁹ University of Navarra and Osasunbidea (Servicio Navarro de Salud), Primary Care Centres, Pamplona, Spain.
²⁰ University Hospital of Álava, Vitoria, Spain.
²¹ University of Málaga, Málaga, Spain.
²² Instituto de la Grasa, Consejo Superior de Investigaciones Científicas, Sevilla, Spain.
²³ Instituto de Investigación Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain.
²⁴ Department of Family Medicine, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain.
²⁵ School of Pharmacy, University of Barcelona, Barcelona, Spain.
²⁶ Instituto Universitario de Investigaciones Biomédicas y Sanitarias (I.U.I.B.S.) de la Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain.
²⁷ Hospital Universitari de Bellvitge-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
²⁸ Primary Care Division, Catalan Institute of Health, Barcelona, Spain.
²⁹ University of Balearic Islands, Spain.
³⁰ University of Basque Country, Spain.
³¹ University of Valencia, Spain.
³² University Hospital Araba, Spain.

PMID: 28392166
DOI: 10.1016/j.clnu.2017.03.015

Abstract

Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods.

Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas.

Results: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46-0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence.

Conclusions: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk.

Trial registration: The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005.

Keywords: Legumes; Lentils; PREDIMED-study; Type 2 diabetes.

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Lukus PK, Doma KM, Duncan AM. Lukus PK, et al. Am J Lifestyle Med. 2020 May 25;14(6):571-584. doi: 10.1177/1559827620916698. eCollection 2020 Nov-Dec. Am J Lifestyle Med. 2020. PMID: 33117097 Review.
Historical Reflection of Food Processing and the Role of Legumes as Part of a Healthy Balanced Diet.
Huebbe P, Rimbach G. Huebbe P, et al. Foods. 2020 Aug 4;9(8):1056. doi: 10.3390/foods9081056. Foods. 2020. PMID: 32759873 Free PMC article. Review.
RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020.
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Association of Dietary Patterns and Type-2 Diabetes Mellitus in Metabolically Homogeneous Subgroups in the KORA FF4 Study.
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Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

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Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

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